diff --git a/Misc/NEWS.d/next/Core and Builtins/2022-03-03-10-46-13.bpo-46841.7CkuZx.rst b/Misc/NEWS.d/next/Core and Builtins/2022-03-03-10-46-13.bpo-46841.7CkuZx.rst
new file mode 100644
index 00000000000000..8be83bcab3c8ec
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2022-03-03-10-46-13.bpo-46841.7CkuZx.rst	
@@ -0,0 +1,2 @@
+Add more detailed specialization failure stats for :opcode:`COMPARE_OP`
+followed by :opcode:`EXTENDED_ARG`.
diff --git a/Python/specialize.c b/Python/specialize.c
index 5486b5b1f65dc9..31cbc437e6731a 100644
--- a/Python/specialize.c
+++ b/Python/specialize.c
@@ -616,6 +616,7 @@ initial_counter_value(void) {
 #define SPEC_FAIL_COMPARE_OP_BASEOBJECT 21
 #define SPEC_FAIL_COMPARE_OP_FLOAT_LONG 22
 #define SPEC_FAIL_COMPARE_OP_LONG_FLOAT 23
+#define SPEC_FAIL_COMPARE_OP_EXTENDED_ARG 24
 
 /* FOR_ITER */
 #define SPEC_FAIL_FOR_ITER_GENERATOR 10
@@ -2080,6 +2081,10 @@ _Py_Specialize_CompareOp(PyObject *lhs, PyObject *rhs, _Py_CODEUNIT *instr,
         *instr = _Py_MAKECODEUNIT(COMPARE_OP, oparg);
         return;
 #endif
+        if (next_opcode == EXTENDED_ARG) {
+            SPECIALIZATION_FAIL(COMPARE_OP, SPEC_FAIL_COMPARE_OP_EXTENDED_ARG);
+            goto failure;
+        }
         SPECIALIZATION_FAIL(COMPARE_OP, SPEC_FAIL_COMPARE_OP_NOT_FOLLOWED_BY_COND_JUMP);
         goto failure;
     }