diff --git a/cpython-windows/build.py b/cpython-windows/build.py
index 638a2c78..190ac9f6 100644
--- a/cpython-windows/build.py
+++ b/cpython-windows/build.py
@@ -1327,6 +1327,25 @@ def build_cpython(
         )
 
         if pgo:
+            if (
+                meets_python_minimum_version(python_version, "3.14")
+                and build_platform == "x64"
+            ):
+                # On 3.14.0a5, PGO cannot be run on ceval so we disable it there
+                # See https://github.com/python/cpython/issues/130004
+                # We should be able to drop this patch in 3.14.0a6
+                exec_and_log(
+                    [
+                        "patch",
+                        "-p1",
+                        "-i",
+                        SUPPORT / "patch-disable-pgo-ceval-3.14.patch",
+                    ],
+                    str(cpython_source_path),
+                    env=os.environ,
+                    exit_on_error=False,
+                )
+
             run_msbuild(
                 msbuild,
                 pcbuild_path,
diff --git a/cpython-windows/patch-disable-pgo-ceval-3.14.patch b/cpython-windows/patch-disable-pgo-ceval-3.14.patch
new file mode 100644
index 00000000..8e96d601
--- /dev/null
+++ b/cpython-windows/patch-disable-pgo-ceval-3.14.patch
@@ -0,0 +1,72 @@
+diff --git a/Python/ceval.c b/Python/ceval.c
+index c6a7a0f841f027..5f8f0ae69ef31b 100644
+--- a/Python/ceval.c
++++ b/Python/ceval.c
+@@ -764,15 +764,10 @@ _PyObjectArray_Free(PyObject **array, PyObject **scratch)
+ #define PY_EVAL_C_STACK_UNITS 2
+ 
+ 
+-/* _PyEval_EvalFrameDefault is too large to optimize for speed with PGO on MSVC
+-   when the JIT is enabled or GIL is disabled. Disable that optimization around
+-   this function only. If this is fixed upstream, we should gate this on the
+-   version of MSVC.
++/* _PyEval_EvalFrameDefault is too large to optimize for speed with PGO on MSVC.
+  */
+ #if (defined(_MSC_VER) && \
+-     defined(_Py_USING_PGO) && \
+-     (defined(_Py_JIT) || \
+-      defined(Py_GIL_DISABLED)))
++     defined(_Py_USING_PGO))
+ #define DO_NOT_OPTIMIZE_INTERP_LOOP
+ #endif
+diff --git a/PCbuild/pyproject.props b/PCbuild/pyproject.props
+index dbdb6b743bea37..17abfa85201a90 100644
+--- a/PCbuild/pyproject.props
++++ b/PCbuild/pyproject.props
+@@ -53,6 +53,7 @@
+     <ClCompile>
+       <AdditionalIncludeDirectories>$(PySourcePath)Include;$(PySourcePath)Include\internal;$(PySourcePath)Include\internal\mimalloc;$(GeneratedPyConfigDir);$(PySourcePath)PC;%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
+       <PreprocessorDefinitions>WIN32;$(_Py3NamePreprocessorDefinition);$(_PlatformPreprocessorDefinition)$(_DebugPreprocessorDefinition)$(_PyStatsPreprocessorDefinition)$(_PydPreprocessorDefinition)%(PreprocessorDefinitions)</PreprocessorDefinitions>
++      <PreprocessorDefinitions Condition="'$(SupportPGO)' and ($(Configuration) == 'PGInstrument' or $(Configuration) == 'PGUpdate')">_Py_USING_PGO=1;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+ 
+       <Optimization>MaxSpeed</Optimization>
+       <IntrinsicFunctions>true</IntrinsicFunctions>
+diff --git a/Python/ceval.c b/Python/ceval.c
+index 1e4f1f3af20aca..c6a7a0f841f027 100644
+--- a/Python/ceval.c
++++ b/Python/ceval.c
+@@ -764,6 +764,23 @@ _PyObjectArray_Free(PyObject **array, PyObject **scratch)
+ #define PY_EVAL_C_STACK_UNITS 2
+ 
+ 
++/* _PyEval_EvalFrameDefault is too large to optimize for speed with PGO on MSVC
++   when the JIT is enabled or GIL is disabled. Disable that optimization around
++   this function only. If this is fixed upstream, we should gate this on the
++   version of MSVC.
++ */
++#if (defined(_MSC_VER) && \
++     defined(_Py_USING_PGO) && \
++     (defined(_Py_JIT) || \
++      defined(Py_GIL_DISABLED)))
++#define DO_NOT_OPTIMIZE_INTERP_LOOP
++#endif
++
++#ifdef DO_NOT_OPTIMIZE_INTERP_LOOP
++#  pragma optimize("t", off)
++/* This setting is reversed below following _PyEval_EvalFrameDefault */
++#endif
++
+ #ifdef Py_TAIL_CALL_INTERP
+ #include "opcode_targets.h"
+ #include "generated_cases.c.h"
+@@ -986,6 +1003,10 @@ _PyEval_EvalFrameDefault(PyThreadState *tstate, _PyInterpreterFrame *frame, int
+     return NULL;
+ }
+ 
++#ifdef DO_NOT_OPTIMIZE_INTERP_LOOP
++#  pragma optimize("", on)
++#endif
++
+ #if defined(__GNUC__)
+ #  pragma GCC diagnostic pop
+ #elif defined(_MSC_VER) /* MS_WINDOWS */